Welcome to Inside the Science - Rethinking Schizophrenia

This section of Inside the Science is dedicated to educating clinicians who care for people living with schizophrenia. Here, you can find videos with experts in the field offering clinical insights and perspectives surrounding the evolving science in schizophrenia.

The video content below will review the current understanding of schizophrenia pathophysiology and established pharmacological targets, as well as discuss the evolving science with a focus on muscarinic receptors.

Please watch to learn more!

Welcome to Inside the Science - Rethinking Schizophrenia

This section of Inside the Science is dedicated to educating clinicians who care for people living with schizophrenia. Here, you can find videos with experts in the field offering clinical insights and perspectives surrounding the evolving science in schizophrenia.

The video content below will review the current understanding of schizophrenia pathophysiology and established pharmacological targets, as well as discuss the evolving science with a focus on muscarinic receptors.

Please watch to learn more!

What Dopaminergic Pathways Are Associated with the Symptoms of Schizophrenia? video thumbnail

What Is the Potential Role of M₁ Receptors in Schizophrenia?

Two muscarinic receptors, M₁ and M₄, are thought to decrease activity in the mesolimbic pathway, where excess dopamine release is linked to positive symptoms of schizophrenia. Learn how the M₁ receptor is thought to impact the mesolimbic pathway by watching this brief video.

Specialty: Neuroscience

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What Dopaminergic Pathways Are Associated with the Symptoms of Schizophrenia?

02:31

What Dopaminergic Pathways Are Associated with the Symptoms of Schizophrenia?

Where Does the Abnormal Dopamine Signaling of Schizophrenia Arise?

01:25

Where Does the Abnormal Dopamine Signaling of Schizophrenia Arise?

What are Muscarinic Receptors?

01:26

What are Muscarinic Receptors?

Why Are We Interested in Muscarinic Modulation of Brain Functioning?

01:53

Why Are We Interested in Muscarinic Modulation of Brain Functioning?

How Does the M1 Receptor Impact Presynaptic Dopamine Release in Specific Striatal Regions?

02:30

How Does the M₁ Receptor Impact Presynaptic Dopamine Release in Specific Striatal Regions?

How Does the M4 Receptor Impact Presynaptic Dopamine Release in Specific Striatal Regions?

01:18

How Does the M₄ Receptor Impact Presynaptic Dopamine Release in Specific Striatal Regions?

What Is the Dopamine Hypothesis of Schizophrenia?

3:00

What Is the Dopamine Hypothesis of Schizophrenia?

What Happens When You Block D2 Receptors?

3:46

What Happens When You Block D₂ Receptors?

What Is Happening Inside of the Pathways That Are Tied to Schizophrenia Symptoms?

2:31

What Is Happening Inside of the Pathways That Are Tied to Schizophrenia Symptoms?

What is Acetylcholine and What are Muscarinic Receptors?

2:28

What is Acetylcholine and What are Muscarinic Receptors?

What Is the Potential Role of Muscarinic Receptors in Schizophrenia?

2:00

What Is the Potential Role of Muscarinic Receptors in Schizophrenia?

What Is the Potential Role of M4 Receptors in Schizophrenia?

2:24

What Is the Potential Role of M₄ Receptors in Schizophrenia?

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